Longitudinal Forced Vital Capacity Monitoring as a Prognostic Adjunct after Lung Transplantation

Forced vital capacity and forced expiratory volume in six seconds as predictors of reduced total lung capacity.

The present study aims to derive guidelines that identify patients for whom spirometry can reliably predict a reduced total lung capacity (TLC). A total of 12,693 lung function tests were analysed on Caucasian subjects, aged 18-70 yrs. Restriction was defined as a reduced TLC. Lower limits of normal (LLN) for TLC were obtained from the European Respiratory Society recommended reference equation...

Incomplete forced expiration - estimating vital capacity by a mathematical method.

BACKGROUND Vital capacity is a key parameter in the determination of lung function, usually assessed by means of a forced expiration maneuver. This maneuver can be exhausting, and patients often cannot complete it. OBJECTIVES This study evaluates a method to estimate forced vital capacity (FVC) based on the extrapolation of volume-time curves from forced expiration. METHODS The algorithm wa...

Forced Vital Capacity (FVC) and Forced Vital Capacity in 1 Second (FEV1) of Apparently Healthy Non-smoker Adult Obese

Is forced expiratory volume in six seconds a valid alternative to forced vital capacity?

We have read with interest the article by HANSEN et al. [1] in a recent issue of the European Respiratory Journal, stating that the use of forced expiratory volume in six seconds (FEV6) reduces the sensitivity of obstructive lung disease detection. Their study population of 3,515 current smokers, with a 17.5% prevalence of obstruction, found a sensitivity of only 76.8% and a specificity of 98.2...

Association of Forced Vital Capacity with the Developmental Gene NCOR2

BACKGROUND Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental exposures and genes affecting lung development as risk factors for low FVC later in life. Although highly heritable, a small number of genes have been f...